Hzf regulates adipogenesis through translational control of C/EBPα

Prolonged Induction Activates Cebpα Independent Adipogenesis in NIH/3T3 Cells

BACKGROUND 3T3-L1 cells are widely used to study adipogenesis and insulin response. Their adipogenic potential decreases with time in the culture. Expressing exogenous genes in 3T3-L1 cells can be challenging. This work tries to establish and characterize an alternative model of cultured adipocytes that is easier to work with than the 3T3-L1 cells. METHODOLOGY/PRINCIPAL FINDINGS INDUCED CELLS...

CCAR1 regulates adipogenesis through glucocorticoid receptor

Glucocorticoids contribute to adipocyte differentiation by cooperating with transcription factors, such as CCAAT/enhancer-binding protein  (C/EBP), to stimulate transcription of the gene encoding peroxisome proliferatoractivated receptor (PPAR), a master regulator of adipogenesis. However, the mechanism of PPAR gene regulation by glucocorticoids, the glucocorticoid receptor (GR) and its cor...

Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins.

A better understanding of molecular regulation in adipogenesis might help the development of efficient strategies to cope with obesity-related diseases. Here, we report that CCAAT/enhancer-binding protein (C/EBP) β and C/EBPδ, two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40). Genetic knockout (KO) or knockdown (KD) o...

BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling.

Seipin regulates lipid homeostasis by preventing lipid droplet (LD) formation in non-adipocytes but promoting it in developing adipocytes. Here, we report that seipin interacts with 14-3-3β through its N- and C-termini. Expression of 14-3-3β is upregulated during adipogenesis, and its deletion results in defective adipogenesis without affecting key adipogenic transcription factors. We further i...

IL-17 Regulates Adipogenesis, Glucose